Patients scam cancer on mother whose cancer I learned spreads the brain may have new options on treatment for their health. Thanks to research led by Dr. Diana Cittelly, member of the Cancer Center at the University of Colorado (UC), in United States .
The research on Cittelly, published in a journal Clinical Cancer Analysis, specifically examines this role of the receptor on interleukin 13 alpha 2 (IL 13 Ra2).
This is a protein that is found at higher rates on cancer cells that metastasize to other places in the body. Especially a brain and lungs.
We found that patients expressing elevated levels of IL 13 Ra2 on their brain metastases have worse survival than those that express low levels of IL 13 Ra2. But we could not see this correlation when examining primary tumors, explains the doctor from the university of United States .
That was important because it suggested that There is an adaptation on cancer cells when Sony Ericsson’s brain extends, with which we could target it, explains Cittelly.
The expert ends by claiming that we were able to identify a role on this receptor as a tool to promote a proliferation with this growth on a metastasis on a brain.
Current treatments for this cancer on mom have a limited success
Brain metastases from cancer over the female I learned develop between a 15% with this 50% of patients with metastatic cancer over mother. Depending on the cancer subtype of mom.
The Current treatment options for brain metastases , such as surgery, radiotherapy, chemotherapy with targeted therapies, have limited success. And they can worsen neurological function.
Since a 80% on women scam brain metastases on cancer on mother die about a year from their diagnosis, Cittelly and her team hoped to find a way to attack cancer cells. After these ze have spread to the brain.
Working with cells in a laboratory, they identified an IL 13 Ra2 as a possible target for this treatment. Especially since protein has shown vulnerability to treatment that includes Capital t Vehicle cells in clinical trials on brain tumors.
We know that about a cancer about mom , particularly in, there is the greatest on brain metastasis on young women master of science risk. As well as those with HER-2 positive female cancers, or the triple negative mother cancer subset, Cittelly explains.
Woman scam cancer about mom | Bigstock
Still zero we know exactly what subpopulations on cancer cells can actually grow on this brain. But our studies specifically suggest that there are some interactions a brain has that lead to upregulation of the IL receptor 10 Ra2 as a tool to promote proliferation in that environment.
Most of the patients with brain metastases left out of clinical trials
A next step about researchers on United States is starting a collaboration scam experts on CAR-T cells. To better understand how CAR-T cell therapy can target IL 13 Ra2.
With this weather, Cittelly expects to see clinical trials for patients with cancer on the female who had metastasized on a brain. Since they are currently out of clinical trials.
Brain metastasis scam patients are often considered terminal with being excluded over a majority of clinical trials, laments a doctor. Having it can be used for that specific population will be great something.
Then the clinical scenario in, when people already have a brain metastasis , we could head to the IL 13 Ra2 to slow the growth of these metastases and reduce progression, add.
If we can target that protein , we can improve the results of these patients, concludes.