Global Ligases Enzyme Market: Overview
New covalent bonds between two molecules are created by the enzyme called ligase. Same as all enzymes, ligases are embedded with proteins that have a target molecule identification site. This provides an active site for the enzymatic reaction to take place. The type of ligase varies depending on the type of covalent bond that they catalyze such as carbon-nitrogen bond, carbon-carbon bond, and carbon-sulphur bond. The energy of a molecule of Guanosine-5′-triphosphate or Adenosine Triphosphate is used to catalyze the reaction. Aminoacyl tRNA-synthetases is included in ligases that join amino acids to the relative tRNA, which promotes the DNA ligases to bring the two pieces of DNA together. A ligase is also known as a Synthetase. Ligases are one of the 50 enzymes present in the human body. They catalyze reactions involved in the conservation of chemical energy. Ligases catalyze the addition of two molecules, deriving the needed energy from the cleavage of an energy-rich phosphate bond. Such a conversion is of adenosine triphosphate (ATP) into adenosine diphosphate (ADP). A reaction of ligase catalyzing the formation of a carbon-oxygen bond between an amino acid and transfer RNA leads to the formation of the amino acid-RNA ligase bond. Carbon-nitrogen bonds are formed by the action of the same enzyme as peptide synthetases and amide synthetases.
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DNA ligase is an enzyme that regulates irregularities. It generates a break in the strong backbone of double-stranded DNA molecules in the process. It plays an important role in the process of DNA repair and DNA replication. It is responsible for three general functions: sealing repairs in the DNA, connecting Okazaki fragments that are formed during the replication of double-stranded DNA in the cell, and sealing recombination fragments. DNA ligase has the function of forming a bond between the end of an ‘acceptor’ nucleotide and at the end of a ‘donor’ nucleotide. An enzyme is used in food processing as a food additive. It is used to modify the properties of food such as digestibility, shelf life, taste, nutritional content, and texture. Enzymes used in dishwashing detergents and laundry are known as household care enzymes in modern times.
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Global Ligases Enzyme Market: Key Trends
Research activities for sequencing applications, increase in the birth rate, rise in the incidence of infectious diseases, and increase in genetic disorders are key factors that are estimated to boost the global ligases enzyme market. Additionally, a rise in R&D to develop ligases as therapeutic interventions for cancer and other diseases is anticipated to propel the market. However, high sensitivity of the enzyme to factors such as ligase concentration, DNA concentration, temperature, and buffer composition are expected to restrain the market.
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Global Ligases Enzyme Market: Segmentation
The global ligases enzyme market can be segmented based on source, application, end-user, and region. Based on source, the global ligases enzyme market can be classified into microorganisms, animal, and plant. The microorganisms segment can be categorized into bacteria, viruses, and others. In terms of application, the global ligases enzyme market can be divided into polymerase chain reaction, mutation detection, cloning, drug target, and next generation sequencing. Based on end-user, the global ligases enzyme market can be classified into diagnostic centers & hospitals and research institutes.
Global Ligases Enzyme Market: Regional Analysis
In terms of region, the global ligases enzyme market can be divided into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America is expected to be the leading revenue contributor to the global ligases enzymes market. It is also expected to dominate the market during the forecast period. Use of ligases in protein engineering are expected to offer growth opportunities to the market in developing regions such as Latin America, Middle East & Africa, and Asia Pacific.
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Global Ligases Enzyme Market: Competitive Landscape
Prominent players operating in the global ligases enzyme market are Novozymes A/S, DowDuPont Inc., F. Hoffmann-La Roche Ltd., Thermo Fisher Scientific Inc. Koninklijke DSM N.V., BASF SE, AB Enzymes GmbH, Codexis, Inc., Advanced Enzyme Technologies Ltd., AB Enzymes GmbH, Codexis, Inc., and Amano Enzyme among others.
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